Pma Sigma
It is active at nanomolar concentrations and activates NF-κB in a dose-dependent manner.
Pma sigma. 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, Phorbol 12-myristate 13-acetate, TPA Empirical Formula (Hill Notation):. InvivoGen’s PMA is designed to study the NF-κB pathway in cellular assays. Also try PMAxx™ (), a superior alternative to PMA.
PMA Page 3 of 8 165/15 Nirvana at Work Ramintra, Ramintra Road, Anusawari, Bang Khen, Bangkok 102 Thailand Tel :. Empirical Formula (Hill Notation) C 36 H 56 O 8. P8139 Sigma-Aldrich Phorbol 12-myristate 13-acetate ≥99% (TLC), film or powder Synonym:.
PMA is the most common and potent phorbol ester. General description PMA (Phorbol 12-myristate 13-acetate) is an activator of protein kinase C (PKC) and a known tumor promoting agent. PMA also exhibits clastogenic (chromosome-breaking) activity.
C 36 H 56 O 8. 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA CAS Number -29-8. Molecular Weight 616..
66 2 Fax :. PMA is available as a 1 mg lyophilized solid or mM solution in water. 66 2 Call Center :.
PMA causes a wide range of effects in cells and tissues and is a very potent mouse skin tumor promoter 2, 3. Product Description PMA (propidium monoazide) is a photo-reactive DNA-binding dye used in viability PCR (v-PCR) of microorganisms like bacteria, viruses, and fungi. The bottles were incubated at 37 °C for 24 hours.
After centrifugation, the clarified broth was tested for IL-2 production using a Human Interleukin-2 ELISA test kit. Phorbol 12-myristate 13-acetate (PMA) can induce the activity of PLD1 (phospholipase D1) but not PLD2 (phospholipase D2). The PHA control culture yielded <3,000 pg IL-2/10 6 Jurkat cells.
The PMA + PHA test cultures yielded a level of production of IL-2>= 15,000 pg IL-2/10 6 Jurkat cells. Sigma-Aldrich offers a number of PMA products. View information & documentation regarding PMA, including CAS, MSDS & more.
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